Mechanochemical Ni‐Catalysed Arylation of <i>ortho</i> ‐Hydroxyarylenaminones: Synthesis of Isoflavones

This work describes two new synthetic methods for the efficient preparation of isoflavones following Ni-catalysed domino arylation reactions vast range ortho-hydroxyarylenaminones utilising aromatic bromides as well carboxylic acids. The presented protocols tolerated significant variation all coupling partners and enabled synthesis isoflavone library twenty-three representatives. is first communicated precedent where mechanic energy was utilised in cyclisation mode.